Duligotuzumab demonstrated superior activity compared with mono-specific EGFR- or HER3-targeting antibodies in the non-clinical FaDu SCCHN model (16), as well as in human xenograft models derived from SCCHN and NSCLC tumors with acquired resistance to EGFR inhibitors (17). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.