(4) Recently Moser et al. (2004), Calza et al. (2001) prove that NGF can act as a angiogenic factor or indirectly interact with VEGF, promoting the proliferation of brain capillary endothelial cells and selectively inducing angiogenesis after cerebral ischemia, thus making the brain vessels more active in a pathophysiological state. The gene discussed is VEGFA; the disease is brain ischemia.