DNMT1 and malignant colon neoplasm: Here, the main aim of the present study was to identify the role of procaine (as a representative of DNMT inhibitor drugs) combined with other chemotherapeutic drugs such as carboplatin (as a representative of DNMT inhibitor drugs), erlotinib, sodium phenylbutyrate, and vorinostat (as representatives of HDAC inhibitor drugs) in demethylating the whole genome of the HCT116 colon cancer cells.