DNMT1 and colonic neoplasm: However, when procaine was combined with carboplatin, the lower dose (3 μM) has resulted in hypomethylating the whole genome of HCT116 colon cancer cells, and this might indicate the activity of this combination in inactivating DNMT [32, 42], while the higher dose has resulted in hypermethylation of the whole genome compared to control [47, 48].