ACE and hypertensive disorder: The Eighth Joint National Committee [3], American Heart Association/American College of Cardiology/Centers for Disease Control and Prevention [4], and 2014 Guidelines for the Management of Hypertension by the Japanese Society of Hypertension (JSH 2014) [2] have recommended diuretics, calcium channel blockers (CCBs), angiotensin II receptor blockers (ARBs), and angiotensin-converting enzyme (ACE) inhibitors as first-line antihypertensive drugs [5].