INS and Hypoglycemia: However, there was no difference in plasma adrenaline response to subsequent hypoglycaemia in another study in which 2 U/kg insulin was administered subcutaneously to induce 2 episodes of antecedent hypoglycaemia per day for 3 days and one episode on the 4th day that lowered the blood glucose levels to 2.2 mmol/L [46].