For example, Figlewicz et al. [44] and Paranjape and Briski [29] who administered 6.75 U/kg and 12 U/kg insulin, respectively, to induce both antecedent and subsequent hypoglycaemia were unable to achieve a significant reduction in plasma adrenaline response to subsequent hypoglycaemic episode. The gene discussed is INS; the disease is Hypoglycemia.