For example, in nondiabetic humans and mice, glucagon response to subsequent hypoglycaemia is reported to be significantly reduced [14–17, 19, 20, 22–25, 27, 47, 48] whereas studies in nondiabetic rats are inconclusive, with some studies reporting a significant reduction in glucagon responses to subsequent hypoglycaemia [28–31] and others reporting no significant difference [32–36]. This evidence concerns the gene GCG and Hypoglycemia.