Davis et al. [59] tested the effects of different depths of antecedent hypoglycaemia on counterregulatory responses in nondiabetic humans and reported that when the blood glucose level was reduced to 3.9 mmol/L during antecedent episodes only plasma adrenaline and glucagon responses to subsequent hypoglycaemia are significantly reduced whereas blood glucose levels of 3.3 mmol/L or lower during antecedent hypoglycaemia lead to a significant reduction in glucagon, adrenaline, noradrenaline, and growth hormone responses to subsequent hypoglycaemia. The gene discussed is GH1; the disease is Hypoglycemia.