RIPK1 and non-small cell lung carcinoma: In addition to Rac1 activation, RIPK1-driven Src, STAT3, and focal adhesion kinase (FAK) activation as well as RIPK1-independent activation of phosphatidyl inositol 3 kinase, Akt and Erk have been shown to trigger DR5-dependent migration and matrigel invasion of NSCLC cells (140).