This approach offers a novel immunotherapeutic tool via coupling of three cooperating processes: delivering the DR agonist to the malignant cell population, potent activation of DR5-mediated cell death signaling, and recruitment of Fcγ-receptor-carrying immune cells that can mount an immune response against the tumor cells (for a summary of current formulations of DR-agonists, please see Table S1 in Supplementary Material). The gene discussed is TNFRSF10B; the disease is neoplasm.