Indeed, administration of GS-9820 24 h before ABT-199 (to allow Bim upregulation) significantly enhanced cytotoxicity in comparison to ABT-199 treatment alone in Eμ-Tcl1 Tg leukemias, CLL and GS-9820-sensitive diffuse large B-cell lymphoma cell lines (Figure 4c and Supplementary Figures 5 and 7). The gene discussed is BCL2L11; the disease is B-cell chronic lymphocytic leukemia.