Previously, Bim has been identified as a key tumor suppressor in both murine and human cancers, with reduced expression associated with therapeutic resistance.42, 43, 44 To further assess the role of Bim in Tcl1-mediated leukemiagenesis and PI3Kδi therapy, Eμ-Tcl1 Tg animals were crossed with Bim−/− animals. The gene discussed is BCL2L11; the disease is cancer.