TP53 and leukemia: Puma was absent in both, only upregulated following treatment with etoposide and concurrent with p53 induction, demonstrating the integrity of the TP53 pathway in Eμ-Tcl1 Tg leukemias (Supplementary Figure 8c).41 However, significant heterogeneity in basal Bim expression was evident in Eμ-Tcl1 Tg leukemias in comparison to normal B-cells, with the level predictive of overall sensitivity to GS-9820-induced death (Supplementary Figures 8a and b).