In the leukocyte transendothelial migration pathway, the TXK gene, which is a non-receptor tyrosine kinase (with altered expression in ASD, ear infection, IBD, and bacterial and viral infections), specifically regulates IFN- γ gene transcription and the development, function, and differentiation of conventional T cells and nonconventional NKT cells. This evidence concerns the gene NTRK1 and ear infection.