In the Toll-like receptor signaling pathway, as shown in Fig. 3, a, commonly shared, differentially expressed genes include CD14 and LY96 (also known as MD-2), responsible for mediating the lipopolysaccharide response, which itself has been shown to create an autism-like phenotype in murine model systems [44], but has never been linked to the shared biology of ASD, cerebral palsy, dilated cardiomyopathy, muscular dystrophy, and IBD. This evidence concerns the gene LY96 and inflammatory bowel disease.