CASP1 and coronary artery disorder: As shown in Fig. 3, the top ten pathways identified from our Ingenuity Pathway Analysis for upregulated caspase-1 nuclear substrates in coronary artery disease were death receptor signaling, apoptosis signaling, cell cycle control of chromosomal replication, splicesomal cycle, retinoic acid apoptosis signaling, ultraviolet radiation (UVA)-induced mitogen-activated protein kinase (MAPK) signaling, MAPK-extracellular signal-regulated kinase (ERK) pathway, double-strand DNA break repair, telomere extension, and granzyme B signaling.