In the Group A treated with Peg IFNα and Ribavirin alone, we observed a significant decrease of WAI (p < 0.01) after 1, 6 and 12 months; a significant increase of absenteeism (p < 0.001) after 6 and 12 months and at follow-up a decrease of anxiety (p < 0.05) at 6 months and increase of depression (p < 0.01) at 1, 6, 12 and at follow up. Here, IFNA1 is linked to major depressive disorder.