The complex Silybin + phosphatidylcholine (Silybin phytosome was formulated with the addition of Vitamin E) (Lorenzin Spa Italy), it not only increase the response to Peg-IFN and Ribavirin in patients but also reduce depression, anxiety and improve work ability in HCV patients [23].﻿ The gene discussed is IFNA1; the disease is major depressive disorder.