COL18A1 and non-small cell lung carcinoma: A new recombinant human endostatin (code number: YH-16), Endostar, is developed by Simcere-Medgenn Bioengineering Co. Ltd, Nanjing and Yantai, China, and is different from the original endostatin studied by O’Reilly [6, 7], which was approved by the China State Food and Drug Administration (SFDA) for the treatment of non- small cell lung cancer as the first therapy in 2005 [8].