Approximately 80 % of ARMS harbor the reciprocal chromosomal translocation t(2;13) (q35;q14) or the less common variant translocation t(1;13)(p36;q14) in which PAX3 and FOXO1, or PAX7 and FOXO1 genes, respectively, are juxtaposed [2]. Here, FOXO1 is linked to alveolar rhabdomyosarcoma.