Although these proteins have been successfully targeted in human tumours xenografted in animal models, none of them seems to be the universal target suited for the majority of tumour (types) in a clinical setting: These proteins are either present on the majority of tumours but only on a low percentage of tumour (stromal) cells, like VEGFR and αvβ3 integrin, or they are abundantly present in only a limited percentage of tumour (types), like folate receptor, EGFR and HER2. The gene discussed is ERBB2; the disease is neoplasm.