Overall, in addition to the well-known effects of Adiponectin, CRP, and Leptin, the LASSO methods identified multiple biomarkers that have been reported to be associated with obesity and/or obesity related conditions [22–45] and that were largely classified into either a group of hormones or hormone related proteins (Adiponectin, Calcitonin, GH, Leptin, SHBG), or into a group of positive acute phase reactants and other biomarkers of inflammation (C3, CRP, Ferritin, IL-18, MCP-1, vWF, and YKL-40). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.