For example, transforming growth factor-β (TGF-β)/Wnt/Notch/hepatocyte growth factor signaling,7, 8, 9, 10 oncogenic Src or Ras activation,1 cancer stem cells,11, 12, 13 miRNA14 and inflammation15 are all implicated in the induction of EMT, but the exact molecular mechanism of EMT and the key genes that drive EMT remain unknown. The gene discussed is TGFB1; the disease is cancer.