Several reports have shown that PD-L1 expression is a negative prognostic factor in several cancer types, including renal, colorectal, and lung cancers16, 17, 18, but others have reported that PD-L1 is a favorable prognostic factor in metastatic melanomas, NSCLC, and Merkel cell carcinomas21, 22, 31. The gene discussed is CD274; the disease is metastatic melanoma.