INS and diabetes mellitus: We have also investigated the in vivo effect of alendronate on long-bone microarchitecture in rats with insulin-deficient Diabetes, as well as the ex vivo action of this bisphosphonate on BMPC multilineage progression (i.e., the effect of orally administered alendronate on the osteogenic, adipocytic, and chondrogenic potential of BMPC obtained ex vivo from treated animals).