APC and malignant colon neoplasm: In the later stages of cancer development, an altered apoptotic response may lead to resistance to cytotoxic chemotherapic drugs. Apc gene, mutated in Familial Adenomatous Polyposis (FAP) and in the majority of sporadic colon cancers, has been linked to defective apoptosis [2], but the mechanisms underlying its involvement in apoptosis are not fully understood [3].