APC and malignant colon neoplasm: Recently [4], we showed that Pirc rats, mutated in Apc and spontaneously developing large and small intestinal tumours [5], are resistant to apoptosis induced by 1,2-dimethylhydrazine (DMH), an alkylating chemical also inducing oxidative damage [6, 7], which is widely used to induce colon cancer in rodents [8].