Accordingly, several chemotherapic drugs such as Adriamycin, Mitomycin, and Cisplatin activate Irf7 in cancer cell lines [25]. Oas1a and Oasl2 belong to the 2′-5′-oligoadenylate synthetase (OAS) family also induced by IFN and associated with antiviral and apoptotic response [26]. OAS genes have been also associated with response to cytotoxic chemicals such as cyclophosphamide [27] and to radiations [24]. The gene discussed is SMOC1; the disease is cancer.