Studies in signal transducer and activator of transcription (STAT)6 gene-deficient mice have revealed that IL-13 signaling utilizes the JAK-STAT pathway, precisely STAT6, and that mice with targeted removal of STAT6 gene have diminished development of Th2-associated reactions in the GI tract following parasitic infection [70,72,73]. This evidence concerns the gene STAT6 and parasitic infectious disease.