Our results are transferable to other tumour sites, for example endometrial carcinomas or adenocarcinomas of gastroesophageal junction 50, 51 although the interpretation of p53 IHC may not be straightforward for tumours showing longer periods of terminal differentiation allowing for degradation of nonsynonymously mutated p53 protein and interpretation rules may have to be adjusted 52. This evidence concerns the gene TP53 and neoplasm.