TNF and autoimmune disease: Many side effects have been recorded during the relatively short history of utilizing anti-TNF-α in the field of autoimmune diseases such as infectious disease [2], autoimmune disease [3, 4], blood dyscrasia [5, 6], pulmonary fibrosis [7], congestive heart failure [8], and malignancies [9] among other adverse effects such as central and peripheral demyelination of the nervous system and optic neuritis.