Although ARS is most commonly caused by heterozygous mutations in FOXC1 (forkhead box C1) (MIM: 601090) and PITX2 (pituitary homeobox 2) (MIM: 601542),4, 5, 6, 7FOXC1 and PITX2 have also been associated with Peters anomaly (MIM: 604229)5, 8 and some cases of aniridia (MIM: 106210).9 The gene discussed is PITX2; the disease is Axenfeld-Rieger syndrome.