It is also noteworthy that UHRF1 regulates a plethora of other TSGs among which RB1 especially in Jurkat and osteosarcoma cells [31, 39, 40], CDX2, CDKN2A, RUNX3, FOXO4, PPARG, BRCA1 and PLM, in gastric cancer [37], SOCS3 and 3OST2 in endometrial carcinoma [41] as well as BRCA1 in cancer breast cell lines [42]. This evidence concerns the gene BRCA1 and osteosarcoma.