UHRF1 was also shown to be overexpressed in primary non-small cell lung cancer (NSCLC) and its high expression level was associated with an increase in the expression of DNMT1, DNMT3A, and DNMT3B and correlated with hypermethylation of p16INK4A promoter [36]. This evidence concerns the gene DNMT3B and non-small cell lung carcinoma.