Recently, we showed that CD47 activation using 4 N1 (CD47 agonist) peptide induced a significant increase in the expression of both UHRF1 gene and protein in human astrocytoma cell lines U87 and CCF-STTG1 (Grade IV) without affecting their expression in normal human astrocytes NHA [38]. This evidence concerns the gene CD47 and astrocytoma (excluding glioblastoma).