CLDN14 and pelvic inflammatory disease: Children who are homozygous CLDN14 p.(Ala163Val) pass newborn and early hearing tests. The proband’s son (R2010, PID VI-4) was discharged after his test at 1 year of age indicated normal hearing. Preschool testing 4 years later showed significant deterioration of both mid and high frequencies (Fig. 1c). Delayed identification could result from limited testing of high frequencies in the preschool years, often complicated by limited testing tolerance in children.