The difference between the PBS-treated (control) and the FasL–/– GMSC-treated mice did not achieve statistical significance, as assessed by arthritis score, historical score, and serum TNF-α concentration, whereas FasL TF GMSC transplantation significantly decreased the values of the above parameters (apart from serum anti-CII tilts), which are important indexes for the severity of the CIA. This evidence concerns the gene FASLG and arthritic joint disease.