SLC5A2 and heart failure: Recently, the EMPA-REG OUTCOME trial [12–14], which examined the effect of empagliflozin, a sodium glucose-cotransporter 2 inhibitor, in addition to standard therapy on cardiovascular morbidity and mortality in patients with type 2 diabetes at high risk, provided the findings that compared to placebo, empagliflozin significantly reduced the combined cardiovascular endpoint, cardiovascular death, overall mortality, and heart failure hospitalization.