We noted a transient increase, at 1 ng/mL sPD-1 treatment, in cytokine (Fig. 4b–e) release by cells derived from non-ARDS mice over the 0 ng sPD-1 treated group, no such change was seen in cells from ARDS mice vs. 0 ng sPD-1 group (Fig. 4b–e). The gene discussed is HOXD13; the disease is acute respiratory distress syndrome.