MACROD2 and chronic obstructive pulmonary disease: Of the coding variants, we found that rs2143390, predicting a p.(D373=) in GPR126 (p = 0.005, OR = 7.9 (1.6-37.6)), rs6413520 in SFTPD (p.(Ser45=), p = 0.036, OR = 8.2 (1.0-66.4)), rs8040868 in CHRNA3 (p.(Val53=), p = 8.8 × 10−3, OR = 2.0 (1.2-3.2)) and rs41275442 in MACROD2 (p.(Thr100Met), p = 0.049, OR = 2.1 (1.0-4.5)) conferred moderate to high risk for COPD (Table 2).