Refractory DLBCL show DEGs that were significantly enriched in genes involved in mitochondrial oxidative phosphorylation, including UQCR11, COX7C, UQCRQ, NDUFB9, NDUFB10, NDUFC1, ATP5D, ATP5O, ATP5G2, and ATP5J2. DLBCL is a heterogeneous disease and can be subdivided into B-cell receptor, OxPhos, and host response tumors based on the transcriptional profile [36]. The gene discussed is COX7C; the disease is diffuse large B-cell lymphoma.