We assessed the mutation distribution of the major pathways associated with the pathogenesis of DLBCL which including BCR signaling, NF-kB, mammalian target of rapamycin (mTOR), phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt), and JAK/STAT pathways. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.