In contrast, Ko et al. [33] performed ion channel profiling in breast cancer and mentioned a decrease of KCNJ3 expression in p53 mutant breast tumors, which are more likely to be ER negative [34], and an increase in KCNJ3 mRNA expression in ER positive tumors when compared to ER negative samples. This evidence concerns the gene KCNJ3 and breast neoplasm.