It has been recently reported that low USP33 expression in primary CRC tissue was correlated with poor prognosis [13]; however, we found that for advanced patients with CRCLM, the low USP33 expression in primary CRC tissue has no prognostic significance; instead, the expression of USP33 in liver metastases can serve as a predictive factor for both disease recurrence as well as overall survival. The gene discussed is USP33; the disease is colorectal carcinoma.