In the PIK3CA mutated TNBC PDX model (HBCx-4B) a significant reduction in tumor volume (RTV) was observed in mice receiving celecoxib as compared to control mice from day 22 (p=0.03) and until the end of the experiment (day 61, TGI=57%, p=0.01) (Figure 4A). Here, PIK3CA is linked to neoplasm.