SBR grade (p=1.5.10-4), lymph node status (p=1.9.10-3), tumor size (p=1.4.10-5), ER (p=8.4.10-6) and PR (p=8.6.10-6) status as well as PIK3CA mutations (p=0.02) all had prognostic value as measured by the 5-years MFS. The gene discussed is PIK3CA; the disease is neoplasm.