DDX proteins interact with RNAs including rRNAs and mRNAs to perform many normal cellular functions, such as translation initiation, mRNA synthesis, RNA splicing and modification, ribosome and spliceosome assembly, and the transcriptional regulation of the genes involved in DNA repair and proliferation, cell cycle arrest, and apoptosis, highlighting the potentially involvement of DDX proteins in cancer [2-10]. This evidence concerns the gene AKR1C3 and cancer.