Taken together, these data indicated that IL-37b may be a direct inhibitor of JNK/pSmad3L/c-myc signaling and promotes Smad3 phospho-isoform signaling shift from JNK/pSmad3L/c-myc oncogenic signaling to pSmad3C/p21 tumor-suppressive signaling. The gene discussed is MAPK8; the disease is neoplasm.