Zhao et al. [19] reported that IL-37 expression is lower in primary HCC tumor tissues and is associated with tumor progress and poor prognosis.IL-37 mediated anti-tumor immune responses through recruiting CD57+ NK cells to tumor microenvironment in HCC, but the detailed mechanism of IL-37's effect on hepatocarcinogenesis is still unclear. The gene discussed is IL37; the disease is hepatocellular carcinoma.