PIK3R2 and neoplasm: We detected two types of response after PIK3R2 depletion, tumors derived from four lines were almost completely eliminated (H2882, H520, H226, CaLu-1; Figure 4A, Supplementary Figure S3A), whereas tumor from the other two lines (SK-MES-1, EPLC-272H) showed reduced growth, although the response was not as marked (Figure 4B, Supplementary Figure S3B).