NSCLC resistant cells presented a reduced modulation of known BET inhibitors targets [14, 26, 27] such CDKN1A (less up-regulated), IL7R, IL6, CSF2, RUNX2 (less down-regulated), and, in accordance with our protein data, the early down-regulation of MYC was observed only in the sensitive cell lines. The gene discussed is IL6; the disease is non-small cell lung carcinoma.