Finally, OTX015-induced changes in NSCLC and SCLC models strongly overlapped with OTX015 signatures in diffuse large B cell lymphomas [14], with JQ1 signatures in NSCLC [24] and other tumor models [26, 28–30], and also partially overlapped with those of HDAC inhibitors (Figure 4, Supplementary Figures S4–S6). This evidence concerns the gene HDAC9 and non-small cell lung carcinoma.