We also evaluated the effect of OTX015 on a panel of stemness markers in vivo, observing that OTX015 induced significant transcriptional downregulation of NANOG, as well as Musashi-1, CD113 and EpCAM in NSCLC tumors, while it did not have an effect on other pluripotency genes such as Oct4, CD44 and CD24 (Figure 2D). This evidence concerns the gene NANOG and non-small cell lung carcinoma.