Analysis of tumor gene expression in H3122-bearing mice at the end of treatment did not show significant variations for any of the OTX015 canonical targets BRD2, 3 and 4 with respect to vehicle-treated animals (Figure 2C), as observed after in vitro analyses in NSCLC cell lines following OTX015 exposure (data not shown). This evidence concerns the gene BRD2 and neoplasm.