Modulation of MYC, BRDs, HEXIM1, BCL2, CDKN1A, MTHFD1L, SESN3, HIST1H2BJ, HIST2H2BE and HIST1H2BK mRNA levels after 24 h with 500 nM OTX015 showed no correlative tendencies with OTX015 biological outcomes in our panel of sensitive and resistant NSCLC cell lines (Supplementary Figure S2A). The gene discussed is H2BC11; the disease is non-small cell lung carcinoma.