ALK and non-small cell lung carcinoma: A subset analysis of clinical trials PROFILE 1005 and 1007 has reported [31] that in ALK-rearranged advanced NSCLC patients treated with Crizotinib, the intracranial disease control rate (DCR) and ORR at 12 weeks were 56% (62%) and 18% (33%), with a median intracranial time to progression (TTP) of 7 months (13.2 months) in patients with previously untreated (treated) brain metastases, respectively.