However, 1- and 2-year OS rates (76.2% and 64.9%) in our study were similar to those observed by Johung KL et al. (72% and 66%) in a multi-institutional study which provided the largest data set of long-term outcomes for ALK-rearranged NSCLC patients with brain metastases in USA [36]. Here, ALK is linked to non-small cell lung carcinoma.