The bone and brain homing LNCaP-KRT13 cells were found to express serpin B1, plexin A3 and semaphorin 3C, and selective collagen-related ECMs possibly exerting anti-PA, axonal guidance, and adhesion to vascular endothelial cells to support the survival, migration, and adhesion of prostate cancer cells in the bone and brain microenvironment. The gene discussed is SEMA3C; the disease is Familial prostate cancer.