Most notable are the overexpression of serpin B1, an anti-PA inhibitor, possibly is responsible for blocking reactive stroma defense mechanism [31], and semaphorin 3C and plexin A3, known as axon guidance ligand-receptor complexes, that possibly determine the directional movement in prostate cancer to home to brain and bone compared to bone-homing RANKL-LNCaP cells. This evidence concerns the gene SERPINB1 and Familial prostate cancer.