Because cell adhesion through interactions between extracellular matrices (ECMs) and integrins are fundamental to cancer colonization in bone and brain, we conducted a comparative survey of selective ECM genes expressed by LNCaP-KRT13/LNCaP-neo as opposed to LNCaP-RANKL/LNCaP-neo, with the latter known to have restricted metastasis to bone and soft tissues. Here, TNFSF11 is linked to cancer.