KRT13 and Familial prostate cancer: 4) While KRT knockdown did not affect cell morphology, EMT and cancer cell invasion [43], genetically overexpressing KRT13 to levels comparable to those observed in metastatic human cancers and cultured cell lines, drove prostate cancer to undergo EMT, increased cell proliferation, migration, invasion and bone, brain and other soft tissue metastases (Figures 3 and 4).