The bone and brain homing LNCaP-KRT13 cells were found to express serpin B1, plexin A3 and semaphorin 3C, and selective collagen-related ECMs possibly exerting anti-PA, axonal guidance, and adhesion to vascular endothelial cells to support the survival, migration, and adhesion of prostate cancer cells in the bone and brain microenvironment. Here, SERPINB1 is linked to Familial prostate cancer.