Consistent with the ability of KRT13-expressing prostate cancer cells that develop brain metastases, we suggest the expression of neuroendocrine/neuromimicry related genes are responsible for increased communication between prostate cancer cells homing to brain and the local brain microenvironment facilitating prostate tumor growth and survival in the brain (Figure 5D and 5E). The gene discussed is KRT13; the disease is Familial prostate cancer.