E2F1 and central nervous system cancer: Furthermore, increased miR-19a in E2F1-depleted cells largely blocked the effect of si-E2F1 on the suppression the malignant progression and the decreased PPARα expression in glioma cells (Figure 4G), suggesting that E2F1 enhances malignant glioma progression by decreasing PPARα expression in a miR-19a-dependent manner.