In conclusion, we have uncovered a set of transcription factors that impact colony formation and invasion-migration of pancreatic cancer cells through their transcriptional regulation of ARHGEF2. Collectively, oncogenic KRAS promotes signal diversification through this set of TFs which transactivate ARHGEF2 in addition to other target genes needed to mediate the RAS-transformation program. Here, ARHGEF2 is linked to pancreatic neoplasm.