POU2F2 and systemic lupus erythematosus: E2F transcription factors and homeobox proteins were previously identified as targets of miRNA profiling in the work published by Dai et al [14] The relationship between transcription factors and SLE was approached by Azkargorta et al.[22], who found a similarity between the metabolic state for E2F2 deficient T-lymphocytes and that of lupus T-cells, which added new insights into the relationship between SLE and E2F2 deficiency.