Although Tgfbr2 inactivation alone does not cause tumor-related changes, Tgfbr2 conditional knockout mouse models have indicated that Tgfbr2 inactivation in the intestinal epithelium accelerates the development of malignant intestinal tumors in combination with mutations in Apc [17], Kras [18], or Pten [19]. This evidence concerns the gene TGFBR2 and neoplasm.