IFNA1 and systemic lupus erythematosus: Even though differential distribution of IFNs transcripts were observed in all subsets of SLE patients with comparatively higher number of transcripts dysregulated in anti-ENA+ subgroups, it was interesting to observe IFN signaling pathway to be affected specifically in anti-ENA+ patients as predicted by IPA and GSEA (Tables 2 and 3, S3 Table, S11 Fig).