In addition there were 211 commonly dysregulated transcripts (161 elevated and 50 downregulated transcripts) shared by both anti-dsDNA+ and anti-ENA+ SLE patients; whereas 178 transcripts with increased expression and 33 with reduced expression were observed in all subsets of SLE patients (Fig 3A and 3B). The gene discussed is ENAH; the disease is systemic lupus erythematosus.