IFN transcripts were also observed to be uniquely expressed in specific SLE subgroups that are IRF7 (1), IFITM10 (1), IFI27L2 (1), MX1 (1) in anti-dsDNA+ subgroup and OAS1 (1), IRF8 (1), IRF5 (1), IFNG (1), IFNRA2 (1) in anti-dsDNA+ENA+ subgroup (Fig 7, S4 Table). Here, IFI27L2 is linked to systemic lupus erythematosus.