ISG15 and systemic lupus erythematosus: We observed dysregulation of major IFN-inducible gene transcripts in all the three SLE patients’ subsets that included IFI27 (12), LY6E (6), IFI44 (1), IFI6 (1), ISG15 (1), OAS1 (1) (Numbers in parentheses are the count of transcripts of a gene that are differentially expressed) (Fig 7, S4 Table).