Therefore, in this study, as described earlier [13–16], the SLE patients were characterized into different subsets based on their autoantibody profiles (subset I: anti-dsDNA+ or subset II: anti-ENA+ or subset III: anti-dsDNA+ENA+) to identify novel expression patterns of transcripts that would otherwise be missed when studying SLE patients as one common group. This evidence concerns the gene ENAH and systemic lupus erythematosus.