So far, three receptors with distinct cellular expression patterns have been known to interact with LIGHT [24–26]: HVEM (TNFRSF14, CD270) detected on activated DCs, T and B cells, NK cells, monocytes, and endothelial cells [26–28]; LTβR found on follicular DCs and stromal cells and binds LIGHT [25]; and the soluble entity decoy receptor 3 (DcR3) detected on diverse cancer cells such as multiple myeloma and diffuse large B-cell lymphoma [29–31]. The gene discussed is TNFRSF6B; the disease is cancer.