SGLT2-i were associated with a decreased risk of non-severe hypoglycaemia compared with SU (0.16, 0.11, 0.22), but not compared with metformin (0.5, 0.18 to 1.43) or DPP-4-i (1.00, 0.49 to 2.02). This evidence concerns the gene SLC5A2 and Hypoglycemia.