SGLT2-i were also associated with an increased risk of UTI compared with metformin (2.01, 1.01, 3.98), but not SU (1.05, 0.84 to 1.31) or DPP-4-i (0.89, 0.67 to 1.19). The gene discussed is SLC5A2; the disease is bacterial urinary tract infection.