A corroborative evidence for direct relation between the activities of calpains and of ORAI1 channels had been demonstrated in murine model of Duchenne muscular dystrophy, where inhibition of ORAI1 by its specific inhibitor BTP-2 greatly reduced the cytosolic μ-calpain activity in the muscle fibres [39], and in skin keratinocytes, for which Ca2+- and calpain-dependent pathway is necessary for proliferation, differentiation and migration [40]. Here, CAPN2 is linked to Duchenne muscular dystrophy.