The meta-analysis of p14, p15, p73, APC, SOCS1, MGMT, SFRP1, PRDM2, DAPK1, RARβ, IGF2 and hMLH1 genes methylation was performed between HCC tumor tissues vs adjacent tissues and HCC tumor tissues vs normal tissues. The gene discussed is SOCS1; the disease is hepatocellular carcinoma.