The meta-analysis of p14, p15, p73, APC, SOCS1, MGMT, SFRP1, PRDM2, DAPK1, RARβ, IGF2 and hMLH1 genes methylation was performed between HCC tumor tissues vs adjacent tissues and HCC tumor tissues vs normal tissues. This evidence concerns the gene DAPK1 and hepatocellular carcinoma.