For six genes reported in at least three studies between HCC tumor serums and normal serums (Table 3), no evidence of statistical heterogeneity was observed for four genes, including RASSF1A (I2 = 0%), p16 (I2 = 0%), CDH1 (I2 = 0%), RUNX3 (I2 = 0%), GSTP1 (I2 = 0%) and WIF1 (I2 = 0%). The gene discussed is RUNX3; the disease is hepatocellular carcinoma.