Wound migration assays showed that upregulation of Gankyrin significantly increased the migratory speed of SW480 and HCT116 cells, whereas knockdown of Gankyrin abrogated the aforementioned the effect (Figure 4A, Supplementary Figure S2) Furthermore, the transwell matrix penetration assay showed that Gankyrin-overexpressing CRC cells enhanced the invasive capacity, whereas knockdown of Gankyrin inhibited the invasive capacity (Figure 4B, 4C). The gene discussed is PSMD10; the disease is colorectal carcinoma.