Accordingly, inhibition of TFNα leads to reduced tumor growth and metastasis in animal models of breast cancer, including of the Luminal-A subtype [22–32]; (3) The growth-stimulating arm–Epidermal growth factor (EGF) in expressed in breast carcinomas, particularly in tumors of the luminal subtype [33–37]. The gene discussed is EGF; the disease is breast cancer.