Most importantly, when the cells were exposed to TME Stimulation, Zeb1 regulated CD44 and CD24 (and to some extent β1), expression, suggesting that EMT-related processes are connected to the generation of TME-induced tumor cellular heterogeneity and generation of CD44+/β1+ and CD44+/CD24low/− sub-populations. The gene discussed is ZEB1; the disease is neoplasm.