In our study, we chose to expose the tumor cells to simultaneous stimulation by representatives of three arms of the TME: (1) The hormonal arm–represented by estrogen, a key driver of tumor cell proliferation and survival in luminal tumors [1, 21]; (2) The inflammatory arm–represented by the inflammatory cytokine tumor necrosis factor α (TNFα). The gene discussed is TNF; the disease is neoplasm.