Furthermore, YAP1 effectively promoted the proliferation, colony formation, migration, and invasion of BGC-823 GC cells and human immortalized normal gastric mucosa GES-1 cells in vitro. The mechanism was associated with EMT, ERK1/2, α-catenin, and β-catenin, and with lncRNAs including HOTAIR, H19, MALAT1, LATS2-AS1-001, and LATS2. The gene discussed is MALAT1; the disease is gastric cancer.